Major Depressive Disorder (MDD): Clinical Symptoms, Neurotransmitters, and Therapy
Major Depressive Disorder (MDD) is a severe, debilitating neuropsychiatric condition characterized by persistent depressed mood, pervasive anhedonia, and cognitive-affective impairment. Explore modern neurobiological mechanisms beyond the simple monoamine hypothesis—including neuroinflammation, HPA axis dysregulation, BDNF-mediated synaptic atrophy, evidence-based psychotherapy, and modern pharmacotherapies.